Hydrochlorothiazide (HCTZ) should be taken at the same time every day. You decide what works best for you. It doesn’t matter when – morning, noon, or night.
However, HCTZ can make you have to urinate more often than usual. Many people take it in the morning so they are less likely to have to get up and urinate at night.
The same time every day, that's the way!