Doctors don’t know when the best time of day is to take chlorthalidone. Take chlorthalidone at a time you will remember. Be sure to take it at the same time every day. For most people, the effects of chlorthalidone last 24 hours.

Some doctors recommend taking chlorthalidone in the morning. This is because some people pee more right after taking chlorthalidone. If you take chlorthalidone at night, you might not sleep well because of nighttime trips to the bathroom.

A recent study compared people who took their blood pressure pill at night with people who took it first thing in the morning. Those who took them at night had lower blood pressure readings. They also had about half as many heart attacks, strokes, and other heart problems during the 6-year follow-up period. This is compared to people who took their medicine in the morning. But most of the people in this study were taking other blood pressure pills, not chlorthalidone.

Doctors think that blood pressure control while you sleep may be even more important for your health than during the day.  Talk to your doctor about the best time of day to take your blood pressure pill.

The same time every day, that's the way!