Rarely, angiotensin-converting enzyme (ACE) inhibitors can cause serious side effects. A few people taking ACE inhibitors can have an allergic reaction or angioedema. 

Studies found that angioedema occurs in 3 to 7 people out of 1,000 taking an ACE inhibitor. This is the extreme swelling of the face, lips, eyelids, tongue, neck, or throat. It can be a reaction to medicines like ACE inhibitors. Angioedema is life-threatening. The swelling can make breathing very difficult.

If you have had this reaction before, tell your doctor before starting an ACE inhibitor. Some people are at higher risk for having it again.

Seek immediate medical help if you have any of these symptoms while taking an ACE inhibitor:

  • Difficulty breathing
  • Swelling of the face, lips, tongue, or throat

When in doubt, seek medical help!