Should hydrochlorothiazide (HCTZ) be taken with or without food?

Studies and manufacturers support that hydrochlorothiazide (HCTZ) can be taken with or without food.^1-5

There are no food contraindications or interactions noted for HCTZ.^1-5

^References

1. Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension 2004; 43 (1): 4-9.
2. Giudicelli JF, Richer C, Mattei A. Pharmacokinetics and biological effects of captopril and hydrochlorothiazide after acute and chronic administration either alone or in combination in hypertensive patients. Br J Clin Pharmacol 1987; 23 Suppl 1: 51s-63s.
3. Jordo L, Johnsson G, Lundborg P, Persson BA, Regardh CG, Ronn O. Bioavailability and disposition of metoprolol and hydrochlorothiazide combined in one tablet and of separate doses of hydrochlorothiazide. Br J Clin Pharmacol 1979; 7 (6): 563-567.
4. Hydrochlorothiazide [package insert]. Morgantown, WV: Mylan Pharmaceuticals, Inc.; 2011.
5. Ernst ME, Carter BL, Zheng S, Grimm RH, Jr. Meta-analysis of dose-response characteristics of hydrochlorothiazide and chlorthalidone: effects on systolic blood pressure and potassium. Am J Hypertens 2010; 23 (4): 440-446.