Spironolactone is taken by mouth as a pill, usually once a day. It comes in 25, 50, and 100 mg tablets. Depending on why you are taking spironolactone, you may be taking as little as 12.5 mg or as much as 400 mg a day. For example, patients taking spironolactone to treat high blood pressure usually take between 25 and 100 mg a day.
Your doctor will usually give you a dose that has worked well for others with your condition. Your dose may be adjusted depending on how it effects your blood pressure and whether or not you have side effects. Your doctor will help you find the dose that gives you the best results.
Once a day is the way!