Studies and manufacturers report that hydrochlorothiazide (HCTZ) can be taken with or without food.1-5
There are no food contraindications or interactions noted for HCTZ.1-5
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Giudicelli JF, Richer C, Mattei A. Pharmacokinetics and biological effects of captopril and hydrochlorothiazide after acute and chronic administration either alone or in combination in hypertensive patients. Br J Clin Pharmacol 1987; 23 Suppl 1: 51s-63s.
Jordo L, Johnsson G, Lundborg P, Persson BA, Regardh CG, Ronn O. Bioavailability and disposition of metoprolol and hydrochlorothiazide combined in one tablet and of separate doses of hydrochlorothiazide. Br J Clin Pharmacol 1979; 7 (6): 563-567.
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