Studies and manufacturers report that chlorthalidone can be taken with or without food.1,2
There are no food contraindications or interactions noted for chlorthalidone in the manufacturer’s prescribing information or in published studies of its pharmacokinetics.1–5.
References
- Dudkowski C, Karim A, Munsaka M. Effects of food intake on the pharmacokinetics of azilsartan medoxomil and chlorthalidone alone and in fixed-dose combination in healthy adults. Clin Pharmacol drug Dev 2016; 5 (5): 393-398.
- Thalitone (chlorthalidone) [package insert]. East Brunswick, NJ: Casper Pharma LLC; 2018.
- Kountz DS, Goldman A, Mikhail J, Ezer M. Chlorthalidone: the forgotten diuretic. Postgrad Med 2012; 124 (1): 60-66.
- Dhalla I, Gomes T, Yao Z, et al. Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults. Ann Intern Med 2013; (January 1993): 447-456.
- Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension 2004; 43 (1): 4-9.