It is very common for two, three, or even more blood pressure medicines to be taken together. But, there are some blood pressure medicines that should not be taken together.
Some calcium channel blockers should not be used with beta-blockers. Both types of medicines lower heart rate. Using them together could make your heart rate too slow.
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) are another pair that should not be taken together. These two together can cause dangerous side effects like high potassium or kidney disease.