Take spironolactone once a day at the same time every day. It is easier to remember that way. You can take it with or without food. Some people like to take it with a meal to help them remember.

You decide what works best for your schedule. If you take it with food one day – always take it with food. If you’d rather take it without food -- always take it without food. This will keep your blood pressure at a steady level from day to day. It is best if there are no big ups or downs.

Some people use day-of-the-week pillboxes or an alarm to remind them. Use what works for you to stay on schedule.

The same time every day, that’s the way!