People who take small doses of spironolactone (12.5 – 50 mg daily) to lower their blood pressure will usually see their blood pressure go down about 4 weeks after starting the medicine. If you are taking a higher dose (400 mg daily), it may only take 1 week to see your blood pressure go down.
If your blood pressure is not lowered enough, your doctor may increase the dose of medicine. It could take a few more weeks for this higher dose to reach its peak effect.
Less pressure, more health!