How long have angiotensin-converting enzyme (ACE) inhibitors been in use?

There are currently several ACE inhibitors approved for use in the US by the FDA for treatment of high blood pressure.

Table 1: FDA approved ACE inhibitors and the year they were approved^1-14

*Drugs with asterisks beside them have had their brand name equivalents discontinued in the US. The generic versions of these drugs continue to be FDA approved and are available in the US.

References

1. Lotensin [package insert]. Parsippany, NJ: Validus Pharmaceuticals LLC; 2019.
2. Capoten [package insert]. Chestnut Ridge, NY: Par Pharmaceutical; 2017.
3. Epaned [package insert]. Wilmington, MA: Azurity Pharmaceuticals, Inc.; 2020.
4. Vasotec [package insert]. Bridgewater, NJ: Bausch Health US LLC; 2018.
5. Enalaprilat [package insert]. Lake Forest, IL: Hospira, Inc.; 2021.
6. Monopril [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; 2003.
7. Qbrelis [package insert]. Wilmington, MA: Azurity Pharmaceuticals, Inc.; 2020.
8. Prinivil [package insert]. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2021.
9. Zestril [package insert]. Morristown, NJ: Almatica Pharma LLC; 2020.
10. Univasc [package insert]. Smyrna, GA: USB, Inc; 2012.
11. Aceon [package insert]. Cincinnati, OH: Patheon Pharmaceuticals, Inc.; 2017.
12. Accupril [package insert]. New York, NY: Parke Davis, Pfizer; 2021.
13. Altace [package insert]. New York, NY: Pfizer Laboratories; 2022.
14. Mavik [package insert]. Whippany, NJ: Halo Pharmaceutical Inc.; 2017.