Captopril was the first of a new class of oral antihypertensive agents called angiotensin-converting enzyme (ACE) inhibitors.1,2 It was approved for the treatment of hypertension by the US Food and Drug Administration in 1981.
There are currently several ACE inhibitors available in the US3-13:

References
- Cushman DW, Ondetti MA. History of the design of captopril and related inhibitors of angiotensin converting enzyme. Hypertension 1991; 17 (4): 589-592.
- Smith CG, Vane JR. The discovery of captopril. FASEB J 2003; 17 (8): 788-789.
- Prinivil [package insert]. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2016.
- Trandolapril [package insert]. Laurelton, NY: Epic Pharma, LLC; 2017.
- Fosinopril sodium [package insert]. Miami, FL: Ciplo USA Inc; 2015.
- Moexipril hydrochloride [package insert]. Teva Pharmaceuticals USA Inc; 2016.
- Aceon [package insert]. North Chicago, IL: Abbot Laboratories; 2011.
- Altace [package insert]. New York, NY: Pfizer Laboratories; 2017.
- Lotensin [package insert]. Parsippany, NJ: Validus Pharmaceuticals LLC; 2014.
- Vasotec [package insert]. Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2015.
- Zestril [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP 2014.
- Capoten [package insert]. Spring Valley, NY: Par Pharmaceutical Companies, Inc.; 2012.
- Accupril [package insert]. New York, NY: Parke Davis, Pfizer; 2017.