Chlorthalidone is usually taken by mouth as a pill once a day.
Chlorthalidone comes in 25 mg and 50 mg pills. Most people will start with lower doses like 12.5 or 25 mg. The dose can increase to 50 mg or 100 mg if needed but people are not often given these high doses because they cause more side effects.
If you are taking 12.5 mg, you will most likely need to cut a 25 mg pill in half with a pill cutter. You can get a pill cutter from your local pharmacy.
Once a day is the way!